ABSTRACT: Objectives: we tried to demonstrate the regeneration of the central nervous system in multiple sclerosis patients based on the size and number of neural activity of the neurons by the functional Magnetic Resonance imaging (fMRI) technique. Methods: We evaluated 12 multiple sclerosis patients (11 female,1 male) who expanded disability status scale (EDSS) was less than four (EDSS mean 1.54 +/- 1.07 range 1-4). Age of subjects 31,5 +/- 6 (19-50) and duration of disease was ( 4.12 +/- 2.21). Two patients where two weeks after attack and pulse steroid treatment, other patients where stable. 11 subjects in the control group was randomized with a sample of the same age and sex. All patients and control subjects where righthanded. This study was designed by testing of voxel averages in different locations. Results: The lowes and highest activation field numbers in contralateral and ipsilateral hemispheres of the right hand in the patient and control groups separately during tasking. No significant difference was found between the duration of the disease and the total number of activated areas. Conclusions: In conclusion with this experimental study, our findings may support the hypothesis that increased cortical activation areas during motor tasking are related to an increased neural activity that may be a result of new formed neural cells or neuroplasticity. Key words: Multiple sclerosis, Functional MRI, Regeneration
Corresponding Author: Silek H.