Frequency of Hypersensitivity Reactýons to Chemotherapeutic Agents in Children With Cancer
Osman Ozturk1, Fazil Orhan21Department of Pediatrics, Bozok University Faculty of Medicine, Yozgat, Turkey Department of Pediatrics, Bozok University Faculty of Medicine, Yozgat, Turkey, 2Departments of Pediatric Allergy and Immunology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
Objectives: The aim of our study is to identify the frequency and the types of immediate hypersensitivity reactions that might be encountered during chemotherapy usage as well as which chemotherapeutics carry more risk of causing immediate hypersensitiviy reactions, to make the expactations of the units that perform chemotherapies more concrete for at least immediate hypersensitivity reactions and the precautions to be taken. Methods: Sixty one patients with cancer who were hospitalised and treated in the pediatric oncology clinic. The number of total chemotherapeutic drug dosage, the number of total dosage for each chemotherapeutic drug, the number of total hypersensitivity reactions, the number of reactions against each chemotherapeutic agent,the frequency of common hypersensitivity reaction and the frequency of hypersensitivity reaction for each chemotherapeutic agent were calculated. A total of 61 patients were followed. During the study period, 9 of 1992 chemotherapeutic dosages have been determined to cause immediate hypersensitivity reactions. Of the 61 patients followed during the study with the diagnosis of cancer, 8 developed hypersensitivity reaction. Results: It has been determined that the frequency of immediate hypersensitivity reactions against chemotherapeutic drugs was quite low and severe, life-threatening type anaphylactic reactions were not present. Conclusion: We found in the study group that the frequency of immediate hypersensitivity reactions to chemotherapeutic drugs was very low and no life-threatening severe anaphylactic reactions were found. Keywords: Chemotherapeutic drugs, children with cancer, hypersensitivity
Cite This Article
Ozturk O, Orhan F. Frequency of Hypersensitivity Reactýons to Chemotherapeutic Agents in Children With Cancer. EJMI. 2019; 3(3): 214-218
Corresponding Author: Osman Ozturk