Objectives: Changes in serum levels of follicle-stimulating hormone (FSH) and estradiol (E2) due to menopause are the some of the most important factors for osteoporosis (OP). The aim of this study was to evaluate the relationship between bone mineral density (BMD) and reproductive hormone levels in postmenopausal women. Methods: A total of 144 postmenopausal women were divided into two groups according to their BMD, as obtained using dual-energy X-ray absorptiometry; 72 patients with low BMD and 72 healthy subjects. Fasting blood samples were obtained from all participants for serum hormone levels, which were compared between the two groups. Results: The FSH levels were significantly higher in the low BMD group (49.76±27.61 IU/L vs. 57.30±24.83 IU/L, p=0.001), and serum E2 levels were statistically lower in the low BMD group (39.25±22.11 pg/mL vs. 30.12±18.16 pg/ mL, p=0.046). The time elapsed after the onset of menopause was longer in the low BMD group (p=0.002). Conclusion: The low E2 and high FSH levels after the onset of menopause were associated with low BMD in postmenopausal women. According to these findings, considering the higher risk of OP in patients with low E2 and high FSH levels, randomized-prospective studies should be conducted to determine whether prophylactic treatment should be given to this group. Keywords: FSH, estradiol, osteoporosis
Corresponding Author: Karatas G.