New Cooltech Define® Cryoadipolysis Applicators: A Scientific and Comparative Study with Cooltech® Applicators
Gregorio Viera Mármol1, Jorge Villena García11Cocoon Medical S.L.U., Barcelona, Spain
Objectives: The main objective of this study was to obtain data from cryoadipolysis simulations to evaluate the designs of new applicators, and how changing shape, dimensions and cooling temperature can increase fat loss. Methods: The cooling dynamics in the skin and fat of three new Cooltech Define® applicator models, were compared to their marketed Cooltech® counterparts, using 3D designs and multiphysics-simulations were carried out with COMSOL Multiphysics®. Cryoadipolysis treatments were recreated and applying different percentages of ischemia. Variables assessed were: Cooling merit parameter, cooling homogeneity, cooling dynamics of skin and fat, the time required to reach crystallization temperatures (set at 10ºC), fat percentage inside the applicators, and time to hypoesthesia. Results: At 100% ischemia, the new applicators were able to reduce the time to reach 10 ºC by 52-68% and increase the fat reduction percentage by 15-20%. After adjusting the ischemia value, the new applicators had a fat reduction percentage of 49%, 78%, and 74%, while in the previous series were 21%, 25%, and 68%, respectively. Conclusion: New cryoadipolysis applicators reached lower temperature, higher cooling speed, more homogeneous cooling, faster hypoesthesia, and greater fat reduction. However, further clinical studies to assess the reproducibility of these data would be needed. Keywords: Apoptosis, adipocyte, cold, cooling, cryolipolysis, computer modeling, lipolysis, multiphysics simulation software, non-invasive fat removal, non-invasive body contouring, reduction, skin barrier, skin physiology/structure
Cite This Article
Viera Mármol G, Villena García J. New Cooltech Define® Cryoadipolysis Applicators: A Scientific and Comparative Study with Cooltech® Applicators. EJMI. 2019; 3(2): 85-94
Corresponding Author: Gregorio Viera Mármol