E-ISSN 2602-3164
ejmi. 2019; 3(2): 100-102 | DOI: 10.14744/ejmi.2019.16584

Hyperhomocysteinemi in patients with diverticula of the colon

Raziye Turan1, Ahmet Cumhur Cumhur Dulger2, Omer Emecen3, Aysegul Torun Goktas1, Arzu Ayraler4, Selahattin Vural5, Mustafa Yakarisik6
1Department of Anaesthesiology and Reanimation, Giresun University Ilhan Ozdemir Training and Research Hospital, Giresun, Turkey, 2Department of Gastroenterology and Hepatology, Giresun University Ilhan Ozdemir Training and Research Hospital, Giresun, Turkey, 3Department of Biochemistry, Giresun University Ilhan Ozdemir Training and Research Hospital, Giresun, Turkey, 4Department of Family Medicine, Giresun University Ilhan Ozdemir Training and Research Hospital, Giresun, Turkey, 5Department of General Surgery, Giresun University Ilhan Ozdemir Training and Research Hospital, Giresun, Turkey, 6Department of İnternal Medicine, Giresun University Ilhan Ozdemir Training and Research Hospital, Giresun, Turkey

Objectives: Hyperhomocysteinemia (HHcy) have been associated with cerebrovascular events, cardiac diseases and vascular thrombosis. HHcy is caused by cyanocobalamin and folate deficiencies. Diverticula of the colon (DC) is caused by herniation of the colonic mucosa and submucosa. The aim of this study was to evaluate serum homocysteine levels in patients with DC. Methods: We consecutively evaluated 115 patients (65 male, mean age 65±12.1 years) with DC. Baseline serum levels of homocystein, folate and vitamin B12 were retrospectively obtained from hospital data. Plasma homocystein was measured by high performance liquid chromatography with a fluorescence detector. Diagnosis of DC was done by colonoscopy. The chi-squared test and independentt test were used for comparison. Results: DC patients had significantly higher levels of homocysteine compared with normal levels (16.4±11.2 ?g/l; normal ranges 0-12 ?g/l). Otherhand, mean vitamin B12 level was 470±317mg/dl and theme an folate level was 9.3±4.3 mg/dl. According to multiple logistic regression, HHcy developed more with aging and male gender was a strong risk factor for HHcy (all p<0.001). Conclusion: Screening for HHcy should be recommended in subjects with DC. HHcy could also lead to DC. Particularly, elderly male patients with DC should be treated with folate and ciyanocobalamine if laboratory data indicates features of HHcy. Keywords: Colon, diverticula, hyperhomocysteinemia


Cite This Article

Turan R, Dulger A, Emecen O, Torun Goktas A, Ayraler A, Vural S, Yakarisik M. Hyperhomocysteinemi in patients with diverticula of the colon. ejmi. 2019; 3(2): 100-102

Corresponding Author: Turan R.

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