E-ISSN 2602-3164
Ahead of Print | DOI: 10.14744/ejmi.2019.14976

Microorganisms Causing Ventilator-Associated Pneumonia And Their Antibiotic Susceptibility

Edhem Unver1, Aytekin Cikman2, Faruk Karakecili3, Alparslan Koc4, Umut d Binay3, Erdal Karavas5
1Erzincan Binali Yildirim University, Faculty of Medicine, Department of Chest Diseases, Erzincan, Turkey, 2Erzincan Binali Yildirim University, Faculty of Medicine, Department of Medical Microbiology, Erzincan, Turkey, 3Erzincan Binali Yildirim University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Erzincan, Turkey, 4Erzincan Binali Yildirim University, Faculty of Medicine, Department of Anaesthesiology and Reanimation, Erzincan, Turkey, 5Erzincan Binali Yildirim University, Faculty of Medicine, Department of Radiology, Erzincan, Turkey

Objective: The aim of this study was to determine the microorganisms causing ventilator-associated pneumonia (VAP) and investigate their antibiotic susceptibility. Materials and Methods: Patients diagnosed with VAP in the adult intensive care units (ICUs) between January 2015 and December 2018 were included in the study. VITEK 2 (bioMérieux, Marcy l’Etoile, France) automated microbiology system was used to identify microorganisms and to determine their antibiotic susceptibility. Results: Average VAP rates was found 26.51 per 1000 ventilator-days. A single microorganism was isolated in 104 of a total of 105 patients while two microorganisms were isolated in 1 patient. Of the isolated microorganisms, 94.3% (n = 100) were Gram-negative bacteria and 5.7% (n = 6) were Gram-positive bacteria. When the distribution of all microorganisms is examined in order of frequency, 62.2% were found to be Acinetobacter spp., 17.9% Pseudomonas spp., 6.6% Klebsiella pneumoniae, 4.7% Staphylococcus aureus, 3.7% Serratia marcescens, 2.8% Escherichia coli, 0.9% Enterococcus faecium, and 0.9% Stenotrophomonas maltophilia. The most effective antibiotics against Acinetobacter spp. were found to be colistin (96.9%), tigecycline (95%), amikacin (15%) and gentamicin (5%), whereas those the most effective against Pseudomonas spp. were found to be colistin (94.1%), ceftazidime (57.8%), gentamicin (55.5%), ciprofloxacin (50%), amikacin(50%), and piperacillin/tazobactam (42.1%). Conclusion: Acinetobacter spp. was the most common agent in VAP. The fact that Acinetobacter spp., which is resistant to carbapenems, quinolones, piperacillin-tazobactam and cephalosporins, was the most common agent in VAP, can significantly affect the mortality rate of the infection. Keywords: Ventilator-associated pneumonia, Ýntensive care unit, Microorganism, Bacteria, Antibiotic susceptibility.


Cite This Article

Unver E, Cikman A, Karakecili F, Koc A, Binay U, Karavas E. Microorganisms Causing Ventilator-Associated Pneumonia And Their Antibiotic Susceptibility. ejmi. ; (): 0-0

Corresponding Author: Unver E.

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