Investigation of the Effectiveness of Algan Hemostatic Agent in Renal Venous Bleeding Model in Rats
Ahmet Midi1, Ali Kumandaş2, Hüsamettin Ekici3, Sena Arda4, Siyami Karahan5, Ahmet Kaan Şimşek4, Erdem Yeşilada61Department of Pathology, Bahcesehir University Faculty of Medicine, Istanbul, Turkey, 2Department of Surgery, Kırıkkale University Faculty of Veterinary Medicine, Kirikkale, Turkey, 3Department of Pharmacology and Toxicology, Kirikkale University Faculty of Veterinary Medicine, Kirikkale, Turkey, 4Department of Medicine Faculty, Bahcesehir University, Istanbul, Turkey, 5Department of Histology, Kirikkale University Faculty of Veterinary Medicine, Kirikkale, Turkey, 6Department of Pharmacognosy and Phytotherapy, Yeditepe University Faculty of Pharmacy, Istanbul, Turkey
Objectives: Major vascular injury is one of the primary causes of death after trauma, and effective and rapid control of bleeding is important to avoid deaths. Today, many products are available for this purpose, but an ideal product to control life-threatening hemorrhage has not yet been produced and more effective hemostatic products are needed. The purpose of this study was to evaluate the hemostatic efficacy of the novel, plant-based blood-stopper Algan Hemostatic Agent (AHA) in an uncontrolled renal venous hemorrhage model in rats. This is the first application of this model in the literature. Methods: A total of 32 rats aged between 5 and 7 weeks were used in the study. The rats were randomly divided into 4 groups, each consisting of 8 rats. An experimental renal vein hemorrhage was established in all groups. A saline-impregnated sponge was applied to the control group to manage the hemorrhage. AHA was applied topically to the study groups in 3 different formulations: AHA-impregnated gauze, a gel, and lyophilized powder were employed to evaluate the hemorrhage control effect. Results: The duration of bleeding was significantly shorter in the AHA groups compared with the control group. Conclusion: This study demonstrated that AHA appears to be a highly effective hemostatic agent when applied locally in lyophilized, gel, or liquid form, and is beneficial in controlling hemorrhage.
Cite This Article
Midi A, Kumandaş A, Ekici H, Arda S, Karahan S, Şimşek A, Yeşilada E. Investigation of the Effectiveness of Algan Hemostatic Agent in Renal Venous Bleeding Model in Rats. EJMI. 2018; 2(3): 129-132
Corresponding Author: Ahmet Midi