E-ISSN 2602-3164
Ahead of Print | DOI: 10.14744/ejmi.2018.28247

Examination of oxidative stress with thiol-disulphide homeostasis in pediatric cases with otitis media with effusion: a case-control study.

Alper Şen1, Kadir Özdamar1, Ataman Gönel2
1Department of Otorhinolaryngology - Head and Neck Surgery, Harran University, Medical Faculty, Şanlıurfa, Turkey, 2Department of Biochemistry, Harran University, Medical Faculty, Şanlıurfa, Turkey.

Background: In the literature, various pathologies are accused of affecting the development of chronic otitis media with effusion (OME). However, the relationship between OME and oxidative stress (OS) is not fully understood. Objectives: To investigate the OS status in OME cases using thiol-disulphide balance. In addition, the presence of OS is exhibited with total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), Ferric Reducing Antioxidant Power (FRAP), Serum lipid hydroperoxide levels (LOOH) and Advanced oxidation protein products (AOPP). Methods: A total of 150 cases (63 female, 87 male; mean age 5.0 ± 1.3 years; age range: 3-9 years) were included in the study. Patients were divided into two groups according to Sade's classification: Group A for patients with grade 1 and 2 TM retraction and Group B for patients with grade 3 and 4 TM retraction. Blood parameters of group A, group B and control group were compared. Results: Native thiol (SH) and total thiol (SH+SS) values in group A and group B were significantly lower than control group (p <0.05). In group B, the %SS / disulphide (SH) value, %SS / SH+SS value, %SH / SH+SS value were significantly higher than group A (all p values ˂ 0.05). TOS, OSI, LOOH, and AOPP values were significantly higher in group A and group B than control group (p ˂ 0.05). Conclusion: In this study, decrease of thiol content and increase of disulphide content are observed in the pediatric cases of OME.


Cite This Article

Şen A, Özdamar K, Gönel A. Examination of oxidative stress with thiol-disulphide homeostasis in pediatric cases with otitis media with effusion: a case-control study.. ejmi. 2018; (): 0-0

Corresponding Author: Şen A.

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