Objectives: Chronic renal disease is a common clinical problem, the etiology of which has not yet been fully elucidated. Human leukocyte antigen profiling has recently gained popularity as an important new tool for precision medicine approaches. In the present study, directed approaches were applied to understand the distribution of HLA antigens and how different HLA expressions affect the frequency of patients with chronic kidney disease in the Black Sea region. Methods: A total of 156 patients with end-stage renal disease and 216 healthy participants who were not related to the patients were enrolled in the study. Results: The frequency of the HLA B*52 and HLA B*58 alleles was significantly lower and the frequency of the HLA B*40, HLA CW*04, HLA CW*05, HLA DRB1*12, and HLA DQB1*03 alleles was significantly higher in end-stage renal disease patients. Conclusion: The study results indicated that the HLA distribution in end-stage renal disease is different from that of healthy individuals. A significantly larger number of HLA B*40, HLA CW*04, HLA DRBB1*12 and HLA DQB1*03 and fewer HLA B*52 and HLA B*58 haplotypes were observed in patients with chronic renal disease. More studies on this subject are required.
Corresponding Author: Hilmi Kodaz