The etiology of macroglossia has a wide spectrum. One rare cause of macroglossia is amyloid infiltration of the tongue. This infiltration generally occurs through systemic amyloidosis. Primary systemic amyloidosis is an abnormal protein infiltration of the extracellular space without a systemic disease, except in the cases of myeloma and hematological disorders. This abnormal protein is produced by the malignant plasma cells of myeloma, which produce excessive amounts of monoclonal kappa and lambda immunoglobulin light chains. Localized infiltration is much more rare. Presently described is the case of a 79-year-old female patient who sought treatment at the outpatient clinic for macroglossia due to amyloid infiltration.
Corresponding Author: Ahmet Hamdi Kepekci